Nursing Implications Aspirin

Nursing Implications Aspirin

Aspirin has been used as an analgesic, anti-inflammatory drug, and antipyretic for more than 100 years. It is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes in the body. Aspirin works in several different parts of the body to reduce pain, swelling, and inflammation caused by minor injuries or illnesses such as colds, flu symptoms and back pain.

Pharmacodynamics

Aspirin works in various parts of the body to reduce pain, swelling, and inflammation. It’s been shown to improve blood flow by dilating blood vessels and increasing production of nitric oxide (NO), a chemical that helps regulate blood pressure.

Aspirin also works by inhibiting the production of prostaglandins in the body. Prostaglandins are hormone-like substances that are produced by the body and play a role in inflammation responses. Inhibition of these chemicals decreases swelling and pain associated with arthritis or other inflammatory diseases.

Pharmacokinetics

Pharmacokinetics describes the process by which a drug is absorbed, distributed, metabolized and excreted.

Aspirin is a non-steroidal anti-inflammatory drug (NSAID).

It is readily absorbed from the GI tract, reaching peak plasma levels within 2 hours of administration.

It then undergoes hepatic metabolism to form salicylic acid.

Salicylic acid may be conjugated with glucuronide or acetylsulfate to form active metabolites that are excreted in urine after glomerular filtration and reabsorption in tubular cells of kidney.

Mechanism of Action

Aspirin is a non-steroidal anti-inflammatory drug (NSAID). It works by reducing prostaglandin production in the body. These prostaglandins are produced by the body as a response to injury or trauma and they cause pain, swelling and inflammation. Aspirin is used to treat pain and inflammation caused by arthritis, muscle strains, gout and other conditions such as feverish illnesses like flu or chickenpox.

Absorption and Distribution

Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), is readily absorbed from the gastrointestinal tract. Peak plasma concentrations occur within 1 hour after an oral dose and are proportional to the administered dose. Aspirin is distributed widely throughout extravascular spaces and binds rapidly to red blood cells in the capillaries of all tissues; only a small amount crosses into skeletal muscle or adipose tissue. Aspirin undergoes extensive metabolism in the liver and is excreted primarily in urine by glomerular filtration.

Metabolism and Excretion

Aspirin is a nonsteroidal anti-inflammatory drug, or NSAID. It’s used to reduce pain and inflammation in patients with arthritis, headaches, fevers and other conditions. Aspirin acts as an inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, which are responsible for producing prostaglandins that cause pain and inflammation in joints. Because aspirin has many side effects on the gastrointestinal system and cardiovascular system, it should be taken with food or milk if possible to increase efficacy while also decreasing toxicity levels in these areas.

Aspirin is metabolized by conjugation with glucuronide in the liver followed by excretion via urine; therefore its half life is approximately 2 hours

Aspirin works in various parts of the body to reduce pain, swelling, and inflammation.

Aspirin works in various parts of the body to reduce pain, swelling, and inflammation.

Aspirin is an anti-inflammatory drug that has several functions throughout the body. Aspirin reduces pain by inhibiting prostaglandin synthesis (production) and decreasing inflammation. Inflammation plays a role in many chronic diseases as well as acute injuries such as broken bones or torn muscles. Prostaglandins are hormone-like substances made by cells in response to injury or disease which cause blood vessels to dilate and blood platelets to thicken which makes it easier for injured tissue repair itself. COX-1 enzymes are found primarily in your stomach lining where they help protect against stomach ulcers caused by digestive acid but also play a role in regulating platelet aggregation (clumping) at sites of injury like bruises or broken blood vessels due to bleeding from small cuts on your skin from shaving with a razor blade etc..

Aspirin is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and other inflammatory disorders. Aspirin blocks the enzyme cyclooxygenase (COX), which leads to decreased production of prostaglandins in the body. Prostaglandins are hormones that cause pain and inflammation by activating receptors on cells throughout various organs including joints or muscles. There are many different types of NSAIDs available today, but aspirin remains one of the most common due its long history of safe use as well as low side effects when compared with other medications within this class; however, some patients may still experience unwanted side effects such as gastrointestinal issues when taking this medication regularly over an extended period time.”